Im so upset with myself. What number do we call for FDA? My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. It has been one week and she has been acting very anxious since. I gave my black lab mix Simparica for the 1st time on 4/1. The vet has not been able to diagnose a cause. The king cavalier bichon mix seems to be ok just not eating much if at all. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. Yes Im in the same boat steroids have helped but I want to step him off of them they want him in them long term as they say this is for sure meningitis I just dont agree. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. My dog was super sick the first months of his life. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). There is a petition in Australia to have this drug banned through change.org, which I've signed. Saturday he started up the drinking again and threw up his breakfast. They want another blood draw in 3 weeks to see where she is. On 08/06 she threw up. Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file Now we are waiting for the verdict: whether its an infection in his bladder or stones. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). now almost exactly two months later, sick again with a fever and stops eating. I'll be calling them tomorrow. Charlie took the pill on Monday and could not even walk this morning. The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. This was the 2nd does I have him. Is your puppy better now and how long did his symptoms last for? . He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. I never saw a flea because he has a very thick coat. So sorry! I threw him his ball and he actually was interested in it. Never happened before. Will not eat or drink. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. Can blocking GABA receptors also cause inflammation of spine? I will keep a close eye on him and hopefully nothing else come about, we will NEVER take this medication again! Once she is completely healed I am putting her back on those. I had always thought how can something so lethal to fleas an ticks be safe to ingest? I do know that she was a healthy and somewhat energetic 10 year old before the treatment. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. Any response from the company? DO NOT give this poison to your pets. Thursday morning was an awful beginning of the day for our boy. They drew blood & took a fecal sample . He is starting to get better. not eating alor and wants me to rub her tummy constantly . Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Is it just me or does it seem like everyone is in this together? I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. Never again will I be giving my pets any pharma meds. I gave it to her then I looked at the box that said never tested on pregnant dogs . I am SO angry with my vet and so mad at myself for not researching first. Today she has fallen 2 or 3 times in the last 8 hours). Anything I can do for him? My Labradoodle had extreme diarrhea last night. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. Can you tell me if your dog is back to normal now?!?! I finally got him to eat some chicken and he threw that up 2 hours later. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. Thank you all so much!!!! I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. If she had just taken it they could give her Charcoal. Hey carol im so sorry to hear about your dog? Called his vet and they gave no information. Chewable tablets can be given directly to your dog or broken up and mixed with food. I also am seeking information as to if there is a class action suit against this company because there should be. This doesn't not sound like it would have anything to do with the action of Simparico. He has become more aggressive and has been growling at me sometimes when I try to move him. The results are fatal for fleas and ticks but safe for mammals such as your dog. So this month. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. RELATED: Signs Your Dog Might Be Having a Seizure. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. The following list includes the known side effects of Simparica. He had an MRI and it came out good. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . May not be from this med but too strange to at least not think about it. Vet trip and meds $400! The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. The cost of Simparica Trio generally ranges from $2230 per dose depending on the tablet size, number of doses, and source of purchase. I would find another vet for a second opinion. It just dawned on me to look and see if this drug might be the reason. Its been 3 months and she continues to have them. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Those with Diarrhea symptom, did it look like mucus in their pets stool? Different vet. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. Maybe? Gave Simparica to my dog yesterday. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. Mine has tremors once in a while and now I know why! Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Good luck. Very dissapointed with my vet for not informing me of the risk this has on my dog. four times. Somedays he will have 2 and then he will go for a couple days without having any issues. Previously B was on Heartgard and Advantix worked well I guess we switch back. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? She definitely is not herself and behaving strangely. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. I have a happy healthy 14 yr old female bull terrier. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. After reading all of supporting reviews, I will never give him this again. I just started my 80 pound pit on this same medication yesterday. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. But anyways - the other night , his feet collapsed from under him & he fainted . I need to tell my vet to switch! I assume it's getting out of his system. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. We are now at about 45 days since last simparica and he is back to his old self. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. I sure hope we don't have ongoing problems. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. Coton de Tulear. Most of us dog parents use some form of heartworm prevention for our dogs. I am starting to get scared they are both 80 lbs and the other dog is. It's been the worst 2 months. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. The following day he died. If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. Will never use again. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. I just want to cry! Trifexis is much safer and I really don't care about the ticks - I can pull those off. . The next day she had diarrhea. No way I will ever give it to her again. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. I just gave Bentlee my Akita Simparica Trio on the 9th. We are already close to $2000 in Vet bills not counting the poison we bought her. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I hate pills for me so I struggle giving this to him. No diarrhea or vomiting or seizures. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. No more of this med! I don't know if the lump came from it or something else. Our vet recommended putting him on phenobarbital. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. Made the pressured in to by a vet to give Simparica Trio. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. Good appetite and no digestive issues (never had that symptom). My 12 yr-old Chihuahua mix is losing his hair right above his nose. They are also drinking more than normal. So we went home with her on steroids and more antibiotics and denamrin for liver. He had been on it for 4-5 months . Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. I was furious with the drug and the prescriber too. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. I am sure simparica caused a fatal seizure in my boxer. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. She still coughs, sneezes and brings up lots of mucus. I wish every one the best. For: Best of luck. I am interested in the petition and the company's response. 98. He was diagnosed with "Sundowners" . Being in CT where Lyme disease is high it's a relief to have top shelf protection. No more itching but covered in same scabs. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! so what about her puppies I am so worried. This time he is having seizures. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I am so upset - I gave it to him last week and he had an accident in the house. Would appreciate any opinion you all may have. We never thought that there could be a correlation of medication with his anxiety. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. Gave our Bloodhound Simparico Trip on Tuesday on Thursday he got extremely thirsty and was peeing everywhere from drinking so much water. This time I am seeing a little blood or tissue in her stool. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. Im now scared half to death. its only been about 4 days since and its been a steady decline. So sad as he was once a happy healthy dog with no prior health issues. Those jaw spasms have decreased but were pretty alarming in Dec and January. After about 35 days he was back to normal. She has had tremors, very lethargic, drinking lots of water. She walks around as if she is on ice with no control of her back legs. He has been low energy since. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. 2-6 days in vomiting here and there. My dog is 9 yrs old . I feel like it was a massive overdose. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. We are beyond sad and livid! I returned to vet next day with him and was advised he was ok. In other words, they can make it easier to have a seizure in susceptible dogs. Two weeks after I made the post above our girl started having seizures and we had to put her down. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Results are fatal for fleas and ticks but safe for mammals such as your?! On 4/1 really do n't have ongoing problems tissue in her stool ticks those. 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